In our recent question and answer, the pharmacist discusses whether or not hydroxyzine can cause a false-positive for benzodiazepines.

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cindy asked

Will a positive an outcome occur on a 10 point urine medicine test as a benzodiazepine if you space taking hydroxyzine?

At a glance

Hydroxyzine is not recognized to cause false-positives because that benzodiazepines ~ above urine drug tests. However, it has actually been reported to cause false-positives for one more class of drugs, tricyclic antidepressants.



The inquiry of whether or not a details drug or supplement can reason a false-positive ~ above a urine medicine screening is a common one and also a an excellent one come ask.

The most typically utilized tests are urine-based immunoassays, and also they room subject come false positives. Studies that advice drugs connected with producing false-positive results often provide huge lists. Because that example, the adhering to have been reported to cause false-positive because that opioids alone:

Poppy seeds

Immunoassay urine screenings are subject to false-positive based simply on how the exam work:

antitoxin are offered to bind to and react through a stated compound (such as a benzodiazepine). When an antibody finds the link it is spring for and also binds come it; the produces a reaction. Such reactions are taped as a "positive" result.Unfortunately, there is a difficulty with "cross-reactivity". Medicine that space not being tested for deserve to occasionally react v the dorn antibody (i.e. "cross-react"), leading to a "false positive."

As girlfriend are concerned with hydroxyzine, let"s take a look at the drug and see if the is connected with producing false-positive on medicine tests.

What Is Hydroxyzine?


Hydroxyzine is a sedating first-generation antihistamine, structurally regarded meclizine.

It has actually very similar effects to Benadryl (diphenhydramine), an additional first-generation antihistamine, but they space technically in various medication great (hydroxyzine is a "piperazine" antihistamine while Benadryl is one "ethanolamine" antihistamine).

Hydroxyzine HCL Vs. Hydroxyzine Pamoate

Hydroxyzine is accessible as two different salt forms:

Atarax (hydroxyzine HCl)Vistaril (hydroxyzine pamoate)

There is rather a little of dispute regarding the various effects every salt form has. The is frequently thought that Atarax is used more for itching and Vistaril is provided for anxiety and also as a sedative.

While a certain individual may have actually slightly different effects with one or the other, many sources, consisting of the prescribing info for both drugs, state they have actually near-identical pharmacokinetic profiles.

The beginning of effect for both is about 15 come 60 minutes after taking a dose, and also both last roughly 4 to 6 hours. Hydroxyzine pamoate may reason slightly much more sedation, however.

Does Hydroxyzine cause False Positives for Benzodiazepines On drug Tests?


Benzodiazepines are amongst the most commonly prescribed drugs and are supplied for a wide selection of indications, including anxiety disorders, insomnia and as a muscle relaxant.

Drugs in the benzodiazepine class include:

While useful, benzodiazepines can cause physiologicaldependence and have a threat of abuse and misuse. Therefore, they are often consisted of in drug screening tests.

Although there space reports of numerous drugs resulting in false-positives for benzodiazepines on medicine tests (e.g., sertraline, oxaprozin),Hydroxyzine has actually not been linked with it. If you tested confident for a benzodiazepine recently on a urine-based drug test, hydroxyzine likely was not the culprit.

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Nevertheless, hydroxyzine has to be reported to cause a false confident for another course of drugs, tricyclic antidepressants, or TCAs.

One that the most commonly cited studies on urine medicine screening, "Urine drug Screening: Practical overview for Clinicians ", states the following concerning TCA false-positives: